DOI: 10.1007/978-1-4020-8502-4_7Book DOI: 10.1007/978-1-4020-8502-4Pages: -

Human Neural Stem Cells for Biopharmaceutical Applications

Book: Stem Cell Research and Therapeutics
Publisher: Springer Netherlands
Copyright: 2008
ISBN: 978-1-4020-8502-4(Online) 978-1-4020-8501-7(Print)
Subject: Biomedicine, Biomedicine general and Life Sciences, general

1. Stem Cell Sciences UK Ltd. Roger Land Building, Kings Buildings, West Mains Road Edinburgh EH9 3JQ UK

2. Stem Cell Sciences UK Ltd. Roger Land Building, Kings Buildings, West Mains Road Edinburgh EH9 3JQ UK

3. Stem Cell Sciences UK Ltd. Minerva Building 250, Babraham Research Campus Cambridge CB22 3AT UK

4. Stem Cell Sciences UK Ltd. Roger Land Building, Kings Buildings, West Mains Road Edinburgh EH9 3JQ UK

Close

Abstract

Neural stem cells, cells which have the ability to self-renew and to differentiate into three neural lineages, hold great potential for many applications in biomedical research, cellular therapy and drug discovery. However, the use of neural stem cells for these applications has been hampered by the lack of availability of stable, pure cell lines. In this review we describe the recent generation of homogenous, pluripotent, stable mouse and human neural stem (NS) cell lines. These cell lines, which can be generated from both foetal and adult tissue and ES cells, possess many attributes which make them amenable to use in the biopharmaceutical industry, such as ease of scale-up, purity and a stable phenotype over extended passage. These characteristics are discussed, along with the technical, safety and ethical issues associated with the use of NS cells in therapeutic and drug discovery applications.


View the Full Text

4237 Views

Chapter Tools